Metformin Affects Heme Function as a Possible Mechanism of Action

Serotonin release as a possible mechanism of reserpine action.

Mechanism of Action of Heme Oxygenase

The formation of bile pigment from heme by a reconstituted heme oxygenase system containing purified bovine spleen heme oxygenase, NADPH-cytochrome P-450 reductase, and biliverdin reductase was studied under an atmosphere containing '8.'802. The product, bilirubin, was isolated and subjected to mass spectrometry, which revealed incorporation of '*O consistent with a two-molecule mechanism, wher...

Study on Antinociceptive Activity of Different Extracts of Peganum Harmala and Possible Mechanism of Action

The seeds of Peganum harmala L. ( Pgh ) (Zygophyllaceae) have been used in Moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process. The major objective of this paper was to investigate the analgesic effect of ethyl acetate (EAE), butanolic (BE) and aqueous (AqE) extracts of seeds of Peganum harmala and elucided the possible underlying action mechani...

Antidiabetic and In Vivo Antioxidant Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts: A Possible Mechanism of Action

Diabetes mellitus is a metabolic disorder affecting carbohydrate, fat and protein metabolism that affects nearly 10% of the population every year. The treatment of diabetes mellitus has been confined to use of oral hypoglycemic agents and insulin, the former being reported to possess serious side effects. This leads to increasing demand for herbal products with antidiabetic factor with little s...

Metformin affects thyroid function in male rats

An intriguing area of research in type 2 diabetes recently discovered association of metformin therapy with thyroid functional and morphological changes. We aimed to evaluate the external symptoms and biochemical indicators concerning thyroid function in rats treated with metformin. Male wistar rats were randomly divided into four groups: Group (D-/M-), Group (D-/M+), Group (D+/M-), and Group (...